Cell-based therapies for tendon and ligament injuries.
نویسندگان
چکیده
Tendon and ligament injuries have proved difficult to treat effectively. Cell-based therapies offer the potential to harness the complex protein synthetic machinery of the cell to induce a regenerative response rather than fibrous scarring. This article reviews the current state of play with respect to the clinically used cell preparations for the treatment of tendon and ligaments overstrain injuries.
منابع مشابه
Anatomic Spring Ligament and Posterior Tibial Tendon Reconstruction: New Concept of Double Bundle PTT and a Novel Technique for Spring Ligament
A new technique in spring ligament reconstruction using medial half of posterior tibial tendon is demonstrated as a means of supporting the arch. In addition a new concept of double bundle PTT reconstruction based on anatomical attachments of original PTT is presented with the goal of obtaining the full function of PTT.
متن کاملEmerging Applications of Stem Cell and Regenerative Medicine to Sports Injuries.
BACKGROUND The treatment of sports-related musculoskeletal injuries with stem cells has become more publicized because of recent reports of high-profile athletes undergoing stem cell procedures. There has been increased interest in defining the parameters of safety and efficacy and the indications for potential use of stem cells in clinical practice. PURPOSE To review the role of regenerative...
متن کاملUse of platelet-rich plasma for patellar tendon and medial collateral ligament injuries: best current clinical practice.
Platelet-rich plasmas (PRPs) are complex molecular therapies prepared from the patient's own blood through minimal manipulation. Clinical studies examining the efficacy of PRPs to manage patellar tendinopathy and medial collateral ligament (MCL) injuries have been reviewed. We found three controlled trials, two of them randomized, and seven case series in the management of patellar tendinopathy...
متن کاملEngineering tendon and ligament tissues: present developments towards successful clinical products.
Musculoskeletal diseases are one of the leading causes of disability worldwide. Among them, tendon and ligament injuries represent an important aspect to consider in both athletes and active working people. Tendon and ligament damage is an important cause of joint instability, and progresses into early onset of osteoarthritis, pain, disability and eventually the need for joint replacement surge...
متن کاملA systematic review of the use of platelet-rich plasma in sports medicine as a new treatment for tendon and ligament injuries.
OBJECTIVE To evaluate, through a systematic review of the current literature, the evidence-based outcomes of the use of platelet-rich plasma (PRP) for the treatment of tendon and ligament injuries. DATA SOURCES A search of English-language articles was performed in PubMed and EMBASE using keywords "PRP," "platelet plasma," and "platelet concentrate" combined with "tendon" and then "ligament" ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Veterinary clinics of North America. Equine practice
دوره 27 2 شماره
صفحات -
تاریخ انتشار 2011